Rapid urease test provides specific identification of Campylobacter pylori in antral mucosal biopsies. Issue 758 (December 1988)

• Record Type: Journal Article
• Authors: Szeto, M. L.; Pounder, R. E.; Hamilton-Dutoit, S. J.; Dhillon, A. P.
• Is Part Of: Postgraduate medical journal. Volume 64:Issue 758(1988)
• Page Start: 935
• Page End: 936
• Publication Date: 1988-12
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.64.758.935
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : In a prospective study, three antral biopsies were taken from 175 dyspeptic patients during routine endoscopy. One biopsy was inserted immediately into a gel-containing well of a CLOtest slide and two biopsies were sent to histopathology. Using the CLOtest, 84 of the 175 samples (48%) detected urease activity in the gastric biopsy, suggesting infection with Campylobacter pylori. Histopathological examination by two independent observers reported that 93 (52%) of the biopsies contained Campylobacter-like organisms. The CLOtest was found to have a specificity of 1.0 and sensitivity of 0.91, providing a rapid identification of most patients harbouring the organism in their gastric mucus.