Elevated cerebrospinal fluid vasopressin in motor neuron disease. Issue 6 (June 1987)

• Record Type: Journal Article
• Authors: Seckl, J R; Lightman, S L; Guiloff, R J
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 50:Issue 6(1987)
• Page Start: 795
• Page End: 797
• Publication Date: 1987-06
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.50.6.795
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : CSF vasopressin levels were significantly elevated in eight patients with motor neuron disease (2.5 +/- 0.4 pmol/l) compared with controls (0.7 +/- 0.1 pmol/l). CSF oxytocin and plasma vasopressin concentrations were similar in the two groups. This finding may be a primary part of the disease process or an epiphenomenon related to increased autonomic and descending pathway activity secondary to abnormal function and/or loss of anterior horn cells.