The ACE gene and Alzheimer's disease susceptibility. Issue 9 (1st September 2000)

• Record Type: Journal Article
• Authors: Narain, Yolanda; Yip, Agustin; Murphy, Terence; Brayne, Carol; Easton, Douglas; Evans, John Grimley; Xuereb, John; Cairns, Nigel; Esiri, Margaret M; Furlong, Robert A; Rubinsztein, David C
• Is Part Of: Journal of medical genetics. Volume 37:Issue 9(2000)
• Page Start: 695
• Page End: 697
• Publication Date: 2000-09-01
• Subjects: Alzheimer's disease -- ACEgene -- I allele; Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.37.9.695
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene ( ACE) is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged >73 years, we found significantly different ACE genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D alleles were associated with a higher risk compared to DI heterozygotes. While the APO E ε4 allele was strongly associated with AD risk in our series, we found no evidence for an interaction between the APO E and ACE loci. In addition, no interactions were observed between ACE and gender or age at death of the AD cases. A meta-analysis of all published reports (12 case-control series in total) suggested that both the II and ID ACE genotypes are associated with increased AD risk (odds ratio (OR) for II v DD 1.36, 95% confidence interval (CI)=1.13-1.63, OR for DI v DD 1.33, 95% CI=1.14-1.53, p = 0.0002).