Antigen specificities and functional properties of MR1-restricted T cells. (February 2021)
- Record Type:
- Journal Article
- Title:
- Antigen specificities and functional properties of MR1-restricted T cells. (February 2021)
- Main Title:
- Antigen specificities and functional properties of MR1-restricted T cells
- Authors:
- De Libero, Gennaro
Chancellor, Andrew
Mori, Lucia - Abstract:
- Highlights: MR1, a non-polymorphic ubiquitous antigen presenting molecule presents small metabolites to T cells. MR1T cells recognize small drugs and microbial metabolites presented by MR1. MR1T cells also recognize self-metabolites accumulating in tumor cells. MR1T cells are multi-functional and express polyclonal TCR heterodimers. Abstract: MR1 is an MHC class I-like molecule with unique structural and biological features that make it an important member among the molecules involved in antigen presentation to T cells. Distinctive features include ubiquitous expression of the MR1 gene and its monomorphism. Another relevant property is that the MR1 protein appears at very low levels on the plasma membrane and its surface expression is regulated by antigen binding. Finally, the nature of presented antigens differs from those that bind other presenting molecules and includes small metabolites of microbial and self-origin, small drugs and tumor-associated antigens. This opinion paper describes in detail some of those features and discusses recent literature in the field.
- Is Part Of:
- Molecular immunology. Volume 130(2021)
- Journal:
- Molecular immunology
- Issue:
- Volume 130(2021)
- Issue Display:
- Volume 130, Issue 2021 (2021)
- Year:
- 2021
- Volume:
- 130
- Issue:
- 2021
- Issue Sort Value:
- 2021-0130-2021-0000
- Page Start:
- 148
- Page End:
- 153
- Publication Date:
- 2021-02
- Subjects:
- MR1 -- Self-antigen -- Antigen presentation -- MR1T cells
Immunochemistry -- Periodicals
Molecular biology -- Periodicals
Immunochemistry -- Periodicals
Allergy and Immunology -- Periodicals
Molecular Biology -- Periodicals
Immunochimie -- Périodiques
Biologie moléculaire -- Périodiques
Immunochemistry
Molecular biology
Periodicals
Electronic journals
571.96 - Journal URLs:
- http://www.sciencedirect.com/science/journal/01615890 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.molimm.2020.12.016 ↗
- Languages:
- English
- ISSNs:
- 0161-5890
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5900.817700
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 23590.xml