Ethanol-free antisolvent crystallization of glycine by liquefied dimethyl ether. Issue 10 (October 2020)

• Record Type: Journal Article
• Authors: Kanda, Hideki; Katsube, Tsubasa; Hoshino, Rintaro; Kishino, Mitsuhiro; Wahyudiono, ; Goto, Motonobu
• Is Part Of: Heliyon. Volume 6:Issue 10(2020)
• Publication Date: 2020-10
• Subjects: Food science -- Chemical engineering -- Materials -- Chemistry -- Natural product -- Amino acid -- Crystallization -- Antisolvent -- Subcritical fluid; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2020.e05258
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: Liquefied dimethyl ether (DME) was employed as an antisolvent to crystallize glycine from its aqueous solution. The proposed method can be performed at 20–25 °C and has the potential to reduce the energy consumption of drying or crystallizing using ethanol. α-Glycine crystals were successfully obtained from glycine aqueous solutions by mixing in liquefied DME, which was easily removed from the crystals by decompression. Contact with a liquefied DME/water mixture and small γ-glycine crystals resulted in the α-glycine converting to γ-glycine. This was only observed for saturated glycine solutions. We speculated that this conversion occurs via a solution-mediated transition. Pure liquefied DME is not capable of promoting solvent-mediated transitions, so saturated glycine solutions treated with the pure antisolvent can give α-glycine as the sole product. Abstract : Food science, Chemical engineering, Materials, Chemistry, Natural product, Amino acid, Crystallization, Antisolvent, Subcritical fluid.