JCAD expression and localization in human blood endothelial cells. Issue 10 (October 2020)

• Record Type: Journal Article
• Authors: Shigeoka, Manabu; Arimoto, Satomi; Akashi, Masaya
• Is Part Of: Heliyon. Volume 6:Issue 10(2020)
• Publication Date: 2020-10
• Subjects: JCAD (junctional cadherin 5 associated) -- Blood endothelial cell-cell junction -- Inflammation -- Submandibular gland -- Cardiology -- Cardiovascular system -- Pathology -- Oral medicine; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2020.e05121
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: Background: Junctional Cadherin 5 Associated (JCAD) is an endothelial, cell-cell junction protein, and its expression is associated with cardiovascular diseases including atherosclerosis and hypertension. However, to date, there are few studies confirming JCAD expression and precise localization in human tissues by immunohistochemical staining. Methods: JCAD expression and localization was assessed in four human submandibular gland (SMG) specimens by immunohistochemical staining. One specimen of SMG with sialoadenitis was accompanied by severe inflammation and fibrosis, while the other was largely normal. Other two SMGs were accompanied by severe fibrosis because of irradiation. Results: Immunohistochemical analysis of human SMGs revealed JCAD localization at the blood endothelial cell-cell junctions. JCAD expression was more evident in microvessels and arteries in areas affected by inflammation. Conclusions: The localization of JCAD at endothelial cell-cell junctions was confirmed in human tissues. JCAD expression may be affected by pathological conditions. Abstract : JCAD (junctional cadherin 5 associated); Blood endothelial cell-cell junction; Inflammation; Submandibular gland; Cardiology; Cardiovascular system; Pathology; Oral medicine