Glycemic profile of women with normoglycemia and gestational diabetes mellitus during early pregnancy using continuous glucose monitoring system. (November 2020)

• Record Type: Journal Article
• Authors: Singh, Charandeep; Gupta, Yashdeep; Goyal, Alpesh; Kalaivani, Mani; Garg, Vineeta; Bharti, Juhi; Singhal, Seema; Kachhawa, Garima; Kulshrestha, Vidushi; Kumari, Rajesh; Mahey, Reeta; Sharma, Jai B; Bhatla, Neerja; Khadgawat, Rajesh; Gupta, Nandita; Tandon, Nikhil
• Is Part Of: Diabetes research and clinical practice. Volume 169(2020)
• Publication Date: 2020-11
• Subjects: Gestational Diabetes Mellitus -- Pregnancy -- South Asia -- CGMS -- IADPSG criteria -- WHO 2013 criteria; IADPSG International Association of Diabetes and Pregnancy Study Groups -- GDM Gestational diabetes mellitus -- ADA American Diabetes Association -- CGMS Continuous glucose monitoring system -- WHO World Health Organization -- BMI Body mass index -- OGTT Oral glucose tolerance test; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2020.108409
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: The burden of GDM is high in South Asia, but good quality data in early pregnancy are limited. This study evaluated the glycemic patterns in women with normoglycemia and GDM using CGMS. The study found significant differences in different glycemic values between women with GDM and normoglycemia in early pregnancy. The results of this study assume significance, given the prevailing confusion regarding the entity "GDM in early pregnancy". Abstract: Aim: We studied women between 8 and 20 weeks of gestation with the aim of evaluating and comparing those having normoglycemia and GDM according to WHO 2013 criteria. Methods: In this cross-sectional study (2017–2019), eligible pregnant women underwent a 75-g OGTT, followed by placement of a CGMS. Results: Women (n = 96, 58 with normoglycemia and 38 with GDM) were enrolled at 14.0 ± 3.2 weeks of gestation. Mean preprandial, 1-h and 2-h postprandial and peak glucose values were significantly higher in women with GDM. Peak glucose value was achieved 60.0 ± 12.3 and 64.3 ± 11.6 min after meal in the normoglycemia and GDM group, respectively. 24-h mean glucose (5.8 ± 0.6 vs. 5.3 ± 0.4 mmol/L), mean daytime glucose (6.0 ± 0.6 vs. 5.5 ± 0.4 mmol/L) and mean nocturnal glucose (5.4 ± 0.7 vs. 5.0 0 ± 0.5 mmol/L) were significantly higher in women with GDM. Total time spent in range was significantly lower in the GDM group compared to the normoglycemia group (92.1 vs. 98.2%). Conclusions: This study highlights differences in glycemic patterns between women with normoglycemia and GDM in the context of a South Asian population where burden of GDM is high but good quality data in early pregnancy are limited.