Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity. (1st January 2020)

• Record Type: Journal Article
• Authors: Al-Rashood, Sara T.; Hamed, Ahmed R.; Hassan, Ghada S.; Alkahtani, Hamad M.; Almehizia, Abdulrahman A.; Alharbi, Amal; Al-Sanea, Mohammad M.; Eldehna, Wagdy M.
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 35:Number 1(2020)
• Page Start: 831
• Page End: 839
• Publication Date: 2020-01-01
• Subjects: Anti-proliferative -- antioxidants -- apoptosis -- spiroxindoles -- synthesis; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2020.1743281
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic compounds. Interestingly, no much attention has been paid to develop spirooxindole derivatives with dual antioxidant and anticancer activities. In this context, a series of spirooxindoles 6a-p was examined for their anticancer effect towards HepG2 hepatocellular carcinoma and PC-3 prostate cancer cell lines. Spirooxindole 6a was found to be an efficient anti-proliferative agent towards both HepG2 and PC-3 cells (IC50 = 6.9 and 11.8 µM, respectively). Afterwards, spirooxindole 6a was assessed for its apoptosis induction potential in HepG2 cells, where its pro-apoptotic impact was approved via the significant elevation in the Bax/Bcl-2 ratio and the expression levels of caspase-3,