Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy. (1st January 2020)

• Record Type: Journal Article
• Authors: Lin, Yuyan; Zhou, Tao; Bai, Renren; Xie, Yuanyuan
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 35:Number 1(2020)
• Page Start: 1080
• Page End: 1099
• Publication Date: 2020-01-01
• Subjects: PDT -- PS -- porphyrin -- photoactivity -- anti-cancer; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2020.1755669
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cellular delivery, stability, and selectivity for cancerous tissues. This review aims to highlight the developments in porphyrin-based structural modifications, with a specific emphasis on the role of PDT in anticancer treatment and the design of PSs to achieve a synergistic effect on multiple targets.