Serological evidence of West Nile virus infection in human populations and domestic birds in the Northwest of Morocco. (June 2021)

• Record Type: Journal Article
• Authors: Assaid, Najlaa; Arich, Soukaina; Ezzikouri, Sayeh; Benjelloun, Soumaya; Dia, Moussa; Faye, Oumar; Akarid, Khadija; Beck, Cécile; Lecollinet, Sylvie; Failloux, Anna-Bella; Sarih, M'hammed
• Is Part Of: Comparative immunology, microbiology and infectious diseases. Volume 76(2021)
• Publication Date: 2021-06
• Subjects: West Nile virus -- Serology -- Human -- Bird -- Virus neutralization test -- Morocco; Communicable diseases in animals -- Periodicals; Veterinary immunology -- Periodicals; Veterinary microbiology -- Periodicals; Immunology -- Periodicals; Microbiology -- Periodicals; Communicable diseases -- Periodicals; Communicable Diseases -- immunology -- Periodicals; Communicable Diseases -- veterinary -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Veterinary Medicine -- Periodicals; Immunologie -- Périodiques; Microbiologie -- Périodiques; Maladies infectieuses -- Périodiques; Communicable diseases; Immunology; Microbiology; Electronic journals; Periodicals; 636.08969
• DOI: 10.1016/j.cimid.2021.101646
• Languages: English
• ISSNs: 0147-9571

Abstract

Highlights: Detection of anti-WNV antibodies in the sera of human populations. Detection of anti-WNV antibodies domestic birds by cELISA, PRNT and MNT. Prevalence of WNV IgG in human population was 3.29 %. Prevalence of WNV IgG in domestic birds was 2.19 %. Abstract: West Nile virus (WNV) was recently detected in Culex pipiens mosquitoes in Morocco. The aim of this study was to evaluate the seroprevalence of WNV in humans and in domestic birds in two regions of Morocco by the detection of IgG antibodies. Blood samples were obtained from 91 human patients and 92 domestic birds from September to December 2019. All study samples were tested using competitive enzyme-linked immunosorbent assay (cELISA) and WNV neutralization tests (VNT) were performed on positive sera. Of all samples, 4 (4.39 %) humans and 4 (4.34 %) birds were found to be seropositive for flaviviruses by the cELISA test. The VNT revealed that three of the four human samples detected positive by cELISA contained neutralizing antibodies against WNV. Two bird samples were confirmed positive by VNT. These results show a significant seroprevalence of anti-WNV antibodies and therefore suggest the active circulation and exposure of human and bird populations in the northwest of Morocco.