Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors. (1st January 2020)

• Record Type: Journal Article
• Authors: Dizdaroglu, Yazgı; Albay, Canan; Arslan, Tayfun; Ece, Abdulilah; Turkoglu, Emir A.; Efe, Asiye; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 35:Number 1(2020)
• Page Start: 289
• Page End: 297
• Publication Date: 2020-01-01
• Subjects: Pyrazole -- carbonic anhydrase -- molecular docking -- ADME; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2019.1695791
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: In this study, newly synthesised compounds 6, 8, 10 and other compounds (1–5, 7 and 9 ) and their inhibitory properties against the human isoforms hCA I and hCA II were reported for the first time. Compounds 1–10 showed effective inhibition profiles with K I values in the range of 5.13–16.9 nM for hCA I and of 11.77–67.39 nM against hCA II, respectively. Molecular docking studies were also performed with Glide XP to get insight into the inhibitory activity and to evaluate the binding modes of the synthesised compounds to hCA I and II. More rigorous binding energy calculations using MM-GBSA protocol which agreed well with observed activities were then performed to improve the docking scores. Results of in silico calculations showed that all compounds obey drug likeness properties. The new compounds reported here might be promising lead compounds for the development of new potent inhibitors as alternatives to classical hCA inhibitors.