Bergamot essential oil attenuate aluminum-induced anxiety-like behavior through antioxidation, anti-inflammatory and GABA regulation in rats. (November 2020)

• Record Type: Journal Article
• Authors: Cui, Yonghua; Che, Yi; Wang, Hongxin
• Is Part Of: Food and chemical toxicology. Volume 145(2020)
• Publication Date: 2020-11
• Subjects: Aluminum trichloride -- Neurotoxicity -- Anxiety -- Bergamot essential oil; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2020.111766
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: A large number of studies showed that aluminum (Al) has potential neurotoxicity to human and animal bodies. Al-treated animals showed anxiety-like behavior, oxidative stress, neuroinflammation and γ-aminobutyric acid (GABA) changes. Bergamot essential oil (BEO) is a kind of well-known plant extract from the fresh fruit of bergamot. Previous studies suggested that BEO improved mood and relieved symptoms of stress-induced anxiety. This study was designed to study the effects of BEO on anxiety-like behavior, oxidative stress, neuroinflammation and GABA system in aluminum trichloride (AlCl3 ) treated rats. Results showed that AlCl3 exposure induced anxiety-like behavior in the elevated plus maze and the open field test. Moreover, AlCl3 exposure decreased the level of GABA and the activity of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) in the hippocampus (HP) and the frontal cortex (FC). In addition, AlCl3 exposure increased the levels of malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) and the levels of interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in the HP and the FC. To the contrary, co-administration of BEO and AlCl3 improved the anxiety-like behavior, GABA system, oxidative stress and neuroinflammation. These results indicated that BEO can alleviate the anxiety-like behavior of AlCl3 -exposed rats through the combined action of antioxidant, anti-inflammatory and GABA regulation. Highlights: Aluminum exposure induced the anxiety-like behavior. Aluminum exposure induced oxidative damage and neuroinflammation in brain. Aluminum exposure decreased GABA levels in several brain regions. BEO alleviated the aluminum-induced anxiety by antioxidation and anti-inflammatory. BEO alleviated the aluminum-induced anxiety by regulating the level of GABA.