Antenatal biological models in the characterization and research of congenital lower urinary tract disorders. Issue 1 (February 2021)

• Record Type: Journal Article
• Authors: Cao, Kevin Xi; Milmoe, Nathalie Jane; Cuckow, Peter Malcom; Olsen, Lars Henning; Johal, Navroop Singh; Douglas Winyard, Paul Julian; Long, David Andrew; Fry, Christopher Henry
• Is Part Of: Journal of pediatric urology. Volume 17:Issue 1(2021)
• Page Start: 21
• Page End: 29
• Publication Date: 2021-02
• Subjects: Fetal -- Urology -- Bladder exstrophy -- Posterior urethral valves -- Animal models; Pediatric urology -- Periodicals; Urologic Diseases -- Periodicals; Urogenital Diseases -- Periodicals; Urologic Surgical Procedures -- Periodicals; Child; Infant; Urologie pédiatrique -- Périodiques; Appareil urinaire -- Maladies -- Périodiques; Pédiatrie; Urologie; Pediatric urology; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); Electronic journals; Periodicals; Electronic journals; 618.926
• DOI: 10.1016/j.jpurol.2020.11.022
• Languages: English
• ISSNs: 1477-5131

Abstract

Summary: Congenital lower urinary tract disorders are a family of diseases affecting both urinary storage and voiding as well as upstream kidney function. Current treatments include surgical reconstruction but many children still fail to achieve urethral continence or progress to chronic kidney disease. New therapies can only be achieved through undertaking research studies to enhance our understanding of congenital lower urinary tract disorders. Animal models form a critical component of this research, a corner of the triangle composed of human in-vitro studies and clinical research. We describe the current animal models for two rare congenital bladder disorders, posterior urethral valves (PUV) and bladder exstrophy (BE). We highlight important areas for researchers to consider when deciding which animal model to use to address particular research questions and outline the strengths and weaknesses of current models available for PUV and BE. Finally, we present ideas for refining animal models for PUV and BE in the future to stimulate future researchers and help them formulate their thinking when working in this field.