Cover Feature: A Cytotoxic Bis(1, 2, 3‐triazol‐5‐ylidene)carbazolide Gold(III) Complex Targets DNA by Partial Intercalation (Chem. Eur. J. 32/2021). Issue 32 (27th May 2021)

• Record Type: Journal Article
• Authors: van der Westhuizen, Danielle; Slabber, Cathryn A.; Fernandes, Manuel A.; Joubert, Daniël F.; Kleinhans, George; van der Westhuizen, C. Johan; Stander, André; Munro, Orde Q.; Bezuidenhout, Daniela I.
• Is Part Of: Chemistry. Volume 27:Issue 32(2021)
• Page Start: 8229
• Page End: 8229
• Publication Date: 2021-05-27
• Subjects: anticancer -- cytotoxicity -- gold complexes -- mesoionic carbenes -- metallodrugs; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202101553
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : A challenging synthesis yields a bis(carbene) Au I ‐CNC pincer precursor complex that may be oxidized to a remarkably redox‐stable [Au III (CNC)Cl] + cation which shows significant cytotoxicity towards a breast cancer cell line. Electrophoresis, viscometry, and spectroscopic data suggest the likely mode of interaction of the compound with DNA involves partial intercalation, enabling it to potentially target both conventional and unconventional DNA species such as three‐way junctions (in silico data). More information can be found in the Full Paper by O. Q. Munro, D. I. Bezuidenhout, et al. (DOI: 10.1002/chem.202100598 ).