Antibody Seronegativity in COVID-19 RT-PCR–Positive Children. Issue 8 (13th July 2022)

• Record Type: Journal Article
• Authors: Bhatt, Maala; Zemek, Roger L.; Tang, Ken; Malley, Richard; Plint, Amy C.; Pham-Huy, Anne; Dawson, Jennifer; McGahern, Candice; Pelchat, Martin; Arnold, Corey; Galipeau, Yannick; Langlois, Marc-André
• Is Part Of: Pediatric infectious disease journal. Volume 41:Issue 8(2022)
• Page Start: e318
• Page End: e320
• Publication Date: 2022-07-13
• Subjects: COVID-19 -- SARS-CoV-2 -- seroconversion -- seronegative -- children; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000003573
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : This substudy of a prospective case-ascertained household transmission study investigated severe acute respiratory syndrome coronavirus 2 reverse transcription polymerase chain reaction–positive individuals without antibody development and factors associated with nonseroconversion. Approximately 1 of 8 individuals with coronavirus disease 2019 did not seroconvert. Children, particularly the youngest, were approximately half as likely to seroconvert compared with adults. Apart from the absence of fever/chills, individual symptoms did not strongly predict nonseroconversion.