Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer. Issue 3 (14th July 2022)

• Record Type: Journal Article
• Authors: Jotic, Ana; Milovanovic, Jovica; Savic-Vujovic, Katarina; Radin, Zorana; Medic, Branislava; Folic, Miljan; Pavlovic, Bojan; Vujovic, Aleksandar; Dundjerovic, Dusko
• Is Part Of: Dose-response. Volume 20:Issue 3(2022)
• Publication Date: 2022-07-14
• Subjects: advanced laryngeal cancer -- prognostic biomarkers -- tumor-infiltrating lymphocytes -- cytokines -- C-reactive protein; Dose-response relationship (Biochemistry) -- Periodicals; Drugs -- Dose-response relationship -- Periodicals; Drugs -- Physiological effect -- Periodicals; Hormesis -- Periodicals; Dose-Response Relationship, Drug -- Periodicals; Dose-response relationship (Biochemistry); Drugs -- Dose-response relationship; Drugs -- Physiological effect; Periodicals; 571.634
• DOI: 10.1177/15593258221115537
• Languages: English
• ISSNs: 1559-3258

Abstract

Objective: The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer. Material and Methods: A prospective study included 52 patients with advanced laryngeal carcinoma surgically treated at the tertiary referral center. Tumor tissue was immunohistochemically stained for T-cell markers (CD4 and CD8), and levels of cytokines (IL-6 and IL-8) and C-reactive protein were analyzed from blood samples. Results: Overall 3-year survival (OS) of patients included in the study was 69.2% and the disease specific survival (DSS) 72.5%. Higher expression of CD4 + and CD8 + were significant prognostic factors with positive impact on both OS and DSS in univariate analysis, but not in multivariate analysis. Levels of IL-8 were a significant predictor of 3-year OS and DSS survival in patients with advanced laryngeal cancer but not levels of IL-6 and CRP values. Conclusion: Though high expression of CD4 and CD8 were demonstrated in the tumor tissue, but their prognostic role was not established. Higher values of IL-8 proved to be significant negative predictor of DSS. This could further collaborate the inclusion of combination of biomarkers in assessment of favorable treatment choice in patients with advanced laryngeal carcinoma.