The Relationship between Carotid Atherosclerosis, Inflammatory Cytokines, and Oxidative Stress in Middle-Aged and Elderly Hemodialysis Patients. (25th September 2013)

• Record Type: Journal Article
• Authors: Ren, Hongqi; Zhou, Xuan; Luan, Zhiyong; Luo, Xiaomei; Han, Shujing; Cai, Qing; Rui, Wang; Li, Yan
• Other Names: Martín-Malo Alejandro Academic Editor.
• Is Part Of: International journal of nephrology. Volume 2013(2013)
• Publication Date: 2013-09-25
• Subjects: Nephrology -- Periodicals; Nephrology; Kidney Diseases; Nephrology; Periodicals; Periodicals; Fulltext; Internet Resources; Electronic journals; 616.61
• DOI: 10.1155/2013/835465
• Languages: English
• ISSNs: 2090-214X

Abstract

Abstract : Objective . To identify the relationship between microinflammation, oxidative stress, and carotid arterial stiffness in hemodialysis patients. Methods . The CAS β and PWV obtained by ultrasound technology were used to assess carotid arterial stiffness. We divided the patients into either the CAS group or the non-CAS group based on the presence or absence of CAS. The parameters of ALB, Ca, P, TC, HDL, LDL, TG, glucose, creatinine, and hs-CRP levels were routinely tested in both groups of patients. The levels of TNF- α, IL-6, and 8-isoprostane F2 α were measured by ELISA. Results . A total of 42 patients were enrolled in the CAS group and 20 patients were enrolled in the non-CAS group. No significant differences between the CAS group and the non-CAS group were observed with respect to age, dialysis duration, DBP, BUN, Cr, TC, TG, HDL, LDL, and Hb. However, SBP, pulse pressure, and 8-isoprostane levels of the CAS group were higher than those of the non-CAS group. The hs-CRP, TNF- α, and IL-6 levels were elevated in both groups but showed no significant differences. Conclusions . Maintenance of hemodialysis patients exhibits a microinflammatory state that may lead to atherosclerosis. The roles of hypertension and oxidative stress may be more important.