Ribosomopathies: Mechanisms of Disease. Issue 7 (January 2014)

• Record Type: Journal Article
• Authors: Nakhoul, Hani; Ke, Jiangwei; Zhou, Xiang; Liao, Wenjuan; Zeng, Shelya X.; Lu, Hua
• Is Part Of: Clinical medicine insights. Issue 7(2014)
• Publication Date: 2014-01
• Subjects: ribosomopathy -- Diamond-Blackfan anemia (DBA) -- 5q-syndrome -- Schwachman-Diamond syndrome (SDS) -- dyskeratosis congenita (DC) -- cartilage hair hypoplasia (CHH) -- Treacher Collins syndrome (TCS) -- p53; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Hematologic Diseases; Blood -- Diseases; Hematology; Electronic journals; Periodicals; Fulltext; Internet Resources; Periodicals; Periodicals; 616.15
• DOI: 10.4137/CMBD.S16952
• Languages: English
• ISSNs: 1179-545X

Abstract

Ribosomopathies are diseases caused by alterations in the structure or function of ribosomal components. Progress in our understanding of the role of the ribosome in translational and transcriptional regulation has clarified the mechanisms of the ribosomopathies and the relationship between ribosomal dysfunction and other diseases, especially cancer. This review aims to discuss these topics with updated information.