Chinese Herbal Medicine Meets Biological Networks of Complex Diseases: A Computational Perspective. (11th June 2017)

• Record Type: Journal Article
• Authors: Gu, Shuo; Pei, Jianfeng
• Other Names: Rahman Khalid Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2017(2017)
• Publication Date: 2017-06-11
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2017/7198645
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : With the rapid development of cheminformatics, computational biology, and systems biology, great progress has been made recently in the computational research of Chinese herbal medicine with in-depth understanding towards pharmacognosy. This paper summarized these studies in the aspects of computational methods, traditional Chinese medicine (TCM) compound databases, and TCM network pharmacology. Furthermore, we chose arachidonic acid metabolic network as a case study to demonstrate the regulatory function of herbal medicine in the treatment of inflammation at network level. Finally, a computational workflow for the network-based TCM study, derived from our previous successful applications, was proposed.