Diamond-Blackfan syndrome and neutropenia. Issue 9 (September 1991)

• Record Type: Journal Article
• Authors: Schofield, K P; Evans, D I
• Is Part Of: Journal of clinical pathology. Volume 44:Issue 9(1991)
• Page Start: 742
• Page End: 744
• Publication Date: 1991-09
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.44.9.742
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Neutropenia is a rare complication of Diamond-Blackfan syndrome (congenital hypoplastic anaemia). Three patients are reported: all had neutropenia as well as anaemia, and to investigate the cause of the neutropenia culture of bone marrow for granulocyte-macrophage colony forming cells (GMCFCs) was performed. Two cases had a low incidence of GMCFCs, but the third case had a high incidence. These findings suggest that myeloid precursors can be abnormal in Diamond-Blackfan syndrome and that the mechanism of neutropenia may, like that of anaemia, vary from patient to patient.