Risk factors for CMV infection within 100 days posttransplantation in patients with acute leukemia. Issue 3 (20th July 2022)

• Record Type: Journal Article
• Authors: Chen, Juan; Pang, Aiming; Zhao, Yuanqi; Liu, Li; Ma, Runzhi; Wei, Jialin; Chen, Xin; He, Yi; Yang, Donglin; Zhang, Rongli; Zhai, Weihua; Ma, Qiaoling; Jiang, Erlie; Han, Mingzhe; Zhou, Jiaxi; Feng, Sizhou
• Is Part Of: Blood science. Volume 4:Issue 3(2022)
• Page Start: 164
• Page End: 169
• Publication Date: 2022-07-20
• Subjects: Acute leukemia -- Allogeneic hematopoietic stem cell transplantation -- Cytomegalovirus -- Risk factors -- Relapse; Hematology -- Periodicals; Blood -- Periodicals; Hematology; Blood; Hematology; Blood; Electronic journals; Periodicals; 616.15005
• DOI: 10.1097/BS9.0000000000000121
• Languages: English
• ISSNs: 2543-6368

Abstract

Abstract : Objective: To investigate the risk factors for cytomegalovirus (CMV) infection within 100 days and the relationship between early CMV infection and 1-year relapse for patients with acute leukemia following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods: Three hundred fifty-nine patients with acute leukemia who received allo-HSCT at our center between January 2015 and January 2020 were retrospectively reviewed. Results: Of 359 patients, 48.19% (173) patients experienced CMV infection within 100 days posttransplantation. In univariate and multivariate logistic analysis, haploidentical-related donor (HRD) ( P < 0.001; odds ratio [OR], 5.542; 95% confidence interval [CI], 3.186–9.639), and ratio of CD3 + CD8 + cells in lymphocytes <14.825% ( P < 0.001; OR, 3.005; 95% CI, 1.712–5.275) were identified as 2 independent risk factors. One-year relapse rate (RR) between the CMV infection group and the non-CMV infection group was not statistically significant (18.5% vs 19.9%, P = 0.688). When we divided the total cohort into AML, ALL, and MAL subgroups, there were no significant differences as well ( P = 0.138; P = 0.588; P = 0.117; respectively). Conclusion: In conclusion, donor type (HRD) and the insufficient recovery of CD3 + CD8 + cells were independent risk factors for CMV infection within 100 days posttransplantation in patients with acute leukemia. CMV infection within 100 days did not influence the incidence of relapse in 1 year for patients with acute leukemia.