The clinical spectrum of primary lateral sclerosis. (2nd November 2020)

• Record Type: Journal Article
• Authors: Barohn, Richard J.; Fink, John K.; Heiman-Patterson, Terry; Huey, Edward D.; Murphy, Jennifer; Statland, Jeffrey M.; Turner, Martin R.; Elman, Lauren
• Is Part Of: Amyotrophic lateral sclerosis and frontotemporal degeneration. Volume 21(2020)Supplement 1
• Page Start: 3
• Page End: 10
• Publication Date: 2020-11-02
• Subjects: Epidemiology -- prognostic -- survival; 616.839
• DOI: 10.1080/21678421.2020.1837178
• Languages: English
• ISSNs: 2167-8421

Abstract

Abstract: Primary lateral sclerosis is a distinct entity that has recently been classified as a "restricted phenotype" of ALS. It is characterized by a pattern of isolated upper motor neuron involvement that often begins in the legs and spreads diffusely. Distinction from other conditions requires careful consideration of clinical presentation and time course of disease. Mills' Syndrome is a rare unilateral variant of primary lateral sclerosis. Cognitive and behavioral involvement may occur.