Association between Toxoplasma gondii Infection and Nephrotic Syndrome Risk in Children: A Case–Control Study and Systematic Review. (11th August 2022)

• Record Type: Journal Article
• Authors: Sorkhi, Hadi; Mollalo, Abolfazl; Bijani, Ali; Mehravar, Saeed; Pournasrollah, Mohammad; Sadr Moharerpour, Sahar; Rostami, Ali
• Is Part Of: Journal of tropical pediatrics. Volume 68:Number 5(2022)
• Publication Date: 2022-08-11
• Subjects: Toxoplasma gondii -- children -- nephrotic syndrome; Pediatrics -- Periodicals; Tropical medicine -- Periodicals; Pediatrics -- Periodicals; Tropical Medicine -- Periodicals; Environmental Health -- Periodicals; Infant; Child; 618.929883
• DOI: 10.1093/tropej/fmac067
• Languages: English
• ISSNs: 0142-6338

Abstract

Abstract: Some evidence suggests toxoplasmosis as an etiology of nephrotic syndrome (NS) in children; however, no observational study evaluated this relationship. In a case–control study, we enrolled 35 children with NS and 37 healthy children. All participants were examined for anti- Toxoplasma immunoglobulin G and M (IgG and IgM) antibodies using enzyme-linked immunosorbent assay. We also systematically reviewed the literature to assess this relationship. Prevalence of anti- Toxoplasma IgG was 17.4% and 13.5% in cases and controls, respectively, indicating a non-significant association (adjusted odds ratio, 1.22, 95% confidence interval, 0.35–4.41). No subjects were seropositive for IgM. In a systematic review, we found that acute toxoplasmosis can induce NS in some children and anti- Toxoplasma treatment is effective in the remission of NS in these cases. In pediatrics with NS, acute toxoplasmosis should be considered as a neglected causative factor.