Influenza A(H1N1)pdm09 But Not A(H3N2) Virus Infection Induces Durable Seroprotection: Results From the Ha Nam Cohort . (2nd June 2020)

• Record Type: Journal Article
• Authors: Hoa, Le Nguyen Minh; Sullivan, Sheena G; Mai, Le Quynh; Khvorov, Arseniy; Phuong, Hoang Vu Mai; Hang, Nguyen Le Khanh; Thai, Pham Quang; Thanh, Le Thi; Carolan, Louise; Anh, Dang Duc; Duong, Tran Nhu; Bryant, Juliet E; van Doorn, H Rogier; Wertheim, Heiman F L; Horby, Peter; Fox, Annette
• Is Part Of: Journal of infectious diseases. Volume 226:Number 1(2022)
• Page Start: 59
• Page End: 69
• Publication Date: 2020-06-02
• Subjects: influenza A virus -- antibody -- immunity -- H1N1 subtype -- H3N2 subtype -- cohort studies; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiaa293
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Background: The extent to which influenza recurrence depends upon waning immunity from prior infection is undefined. We used antibody titers of Ha-Nam cohort participants to estimate protection curves and decay trajectories. Methods: Households (270) participated in influenza-like–illness (ILI) surveillance and provided blood at intervals spanning laboratory–confirmed virus transmission. Sera were tested in hemagglutination inhibition assay. Infection was defined as influenza virus-positive ILI and/or seroconversion. Median protective titers were estimated using scaled-logistic regression to model pretransmission titer against infection status in that season, limiting analysis to households with infection(s). Titers were modelled against month since infection using mixed-effects linear regression to estimate decay and when titers fell below protection thresholds. Results: From December 2008–2012, 295 and 314 participants were infected with H1N1pdm09-like and A/Perth/16/09-like (H3N2Pe09) viruses, respectively. The proportion protected rose more steeply with titer for H1N1pdm09 than for H3N2Pe09, and estimated 50% protection titers were 19.6 and 37.3, respectively. Postinfection titers started higher against H3N2Pe09 but decayed more steeply than against H1N1pdm09. Seroprotection was estimated to be sustained against H1N1pdm09 but to wane by 8-months for H3N2Pe09. Conclusions: Estimates indicate that infection induces durable seroprotection against H1N1pdm09 but not H3N2Pe09, which could in part account for the younger age of A(H1N1) versus A(H3N2) cases. Abstract : To estimate the duration of seroprotection following influenza infection we modelled the protective effects, and decay, of hemagglutination inhibiting antibodies. A(H1N1) but not A(H3N2) infection induced durable seroprotection, and accordingly A(H1N1) predominantly infected children whereas A(H3N2) infected all age groups.