TCM herbal prescription recommendation model based on multi-graph convolutional network. (28th October 2022)

• Record Type: Journal Article
• Authors: Zhao, Wen; Lu, Weikai; Li, Zuoyong; Zhou, Chang'en; Fan, Haoyi; Yang, Zhaoyang; Lin, Xuejuan; Li, Candong
• Is Part Of: Journal of ethnopharmacology. Volume 297(2022)
• Publication Date: 2022-10-28
• Subjects: Artificial intelligence -- Graph convolutional network -- TCM herbal Prescription -- N-ary relationship -- Intelligent recommendation; TCM traditional Chinese medicine -- AI artificial intelligence -- MGCN multigraph convolutional network -- Se symptom-'state element'-symptom graph -- Ts symptom-'syndrome-type'-symptom graph -- MLP multilayer perceptron -- SVM support vector machine -- LR logistic regression -- PTM potential topic model -- GCN graph convolutional network -- OvR one-vs-rest -- SeGCN state-element graph convolutional network -- TsGCN TCM syndrome-type graph convolutional network; Ethnopharmacology -- Periodicals; Pharmacognosy -- Periodicals; Herbs -- Periodicals; Herbs -- Periodicals; Pharmacognosy -- Periodicals; Pharmacognosie -- Périodiques; Herbes -- Périodiques; 615.1
• DOI: 10.1016/j.jep.2022.115109
• Languages: English
• ISSNs: 0378-8741

Abstract

Abstract: Ethnopharmacological relevance: The recommendation of herbal prescriptions is a focus of research in traditional Chinese medicine (TCM). Artificial intelligence (AI) algorithms can generate prescriptions by analysing symptom data. Current models mainly focus on the binary relationships between a group of symptoms and a group of TCM herbs. A smaller number of existing models focus on the ternary relationships between TCM symptoms, syndrome-types and herbs. However, the process of TCM diagnosis (symptom analysis) and treatment (prescription) is, in essence, a "multi-ary" ( n -ary) relationship. Present models fall short of considering the n -ary relationships between symptoms, state-elements, syndrome-types and herbs. Therefore, there is room for improvement in TCM herbal prescription recommendation models. Purpose: To portray the n -ary relationship, this study proposes a prescription recommendation model based on a multigraph convolutional network (MGCN). It introduces two essential components of the TCM diagnosis process: state-elements and syndrome-types. Methods: The MGCN consists of two modules: a TCM feature-aggregation module and a herbal medicine prediction module. The TCM feature-aggregation module simulates the n -ary relationships between symptoms and prescriptions by constructing a symptom-'state element'-symptom graph ( S e ) and a symptom-'syndrome-type'-symptom graph ( T s ). The herbal medicine prediction module inputs state-elements, syndrome-types and symptom data and uses a multilayer perceptron (MLP) to predict a corresponding herbal prescription. To verify the effectiveness of the proposed model, numerous quantitative and qualitative experiments were conducted on the Treatise on Febrile Diseases dataset. Results: In the experiments, the MGCN outperformed three other algorithms used for comparison. In addition, the experimental data shows that, of these three algorithms, the SVM performed best. The MGCN was 4.51%, 6.45% and 5.31% higher in Precision@5, Recall@5 and F1-score@5, respectively, than the SVM. We set the K -value to 5 and conducted two qualitative experiments. In the first case, all five herbs in the label were correctly predicted by the MGCN. In the second case, four of the five herbs were correctly predicted. Conclusions: Compared with existing AI algorithms, the MGCN significantly improved the accuracy of TCM herbal prescription recommendations. In addition, the MGCN provides a more accurate TCM prescription herbal recommendation scheme, giving it great practical application value. Graphical abstract: Image 1