142 Discordance between neurologists and people with MS on the presence and burden of cognitive impairment. Issue 9 (12th August 2022)

• Record Type: Journal Article
• Authors: Penner, Iris Katharina; Heras, Virginia de las; Jones, Eddie; Castro, Patricia Dominguez; Bezlyak, Vladimir; Piani-Meier, Daniela; Lines, Carol
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 93:Issue 9(2022)
• Page Start: e2
• Publication Date: 2022-08-12
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2022-abn2.186
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Introduction: Approximately 34%-65% of people with multiple sclerosis (pwMS) develop cognitive impair- ment (CI). CI often encompasses information processing speed, memory problems, difficulty concentrat- ing, and problems using executive functions effectively. This study explores the perception of the presence of CI from the perspectives of pwMS and neurologists. Methods: US, UK and EU retrospective data analysis from the 2011-2019 Adelphi Multiple Sclerosis Disease- Specific Programme (MS-DSP). The MS-DSP is a database where neurologists provide data on the next 10 pwMS to have a consultation, patient record form (PRF), integrated with pwMS self-reported data, patient self-completion form (PSC). Neurologists and pwMS were asked about the presence of problems concentrating. Results: 25, 374 pwMS had a PRF. 11, 220 pwMS had a PRF and PSC, of these 4294 answered the cognition section, with 62% (n=2, 643) reporting CI (mild 36.8%, moderate 18.6, or extreme 6.1% problems concen- trating) in the past two weeks. For the same pwMS, neurologists reported 27% (n=1, 158) currently having CI (mild 19.9%, moderate 6.8%, or severe 0.3% problems concentrating). Conclusions: A clear discordance is observed between neurologists and pwMS on their perception of the presence and severity of CI with neurologists clearly underestimating the existence. Funding: Novartis Pharma AG, Basel, Switzerland.