Association between prenatal and perinatal factors and the severity of clinical presentation of children with ASD: Report from the ELENA COHORT. (May 2021)

• Record Type: Journal Article
• Authors: Traver, Sabine; Geoffray, Marie-Maude; Mazières, Lucile; Geneviève, David; Michelon, Cécile; Picot, Marie-Christine; Baghdadli, Amaria
• Is Part Of: Journal of psychiatric research. Volume 137(2021)
• Page Start: 634
• Page End: 642
• Publication Date: 2021-05
• Subjects: Autism spectrum disorder -- Severity -- Adaptive functioning -- Prenatal -- Perinatal -- Neurodevelopment; Psychiatry -- Periodicals; Mental Disorders -- Periodicals; Maladies mentales -- Périodiques; Psychiatry; Electronic journals; Periodicals; 616.89005
• DOI: 10.1016/j.jpsychires.2020.11.005
• Languages: English
• ISSNs: 0022-3956

Abstract

Abstract: Many studies have suggested that prenatal and perinatal factors increase the risk for autism spectrum disorder (ASD). However, few reports have addressed the question of their influence on the severity of the clinical presentation of children with ASD. Our objective was to determine the prenatal and perinatal factors that are associated with the severity of autistic symptoms and intellectual and adaptive functioning deficits. Data were collected from a subset of 169 children with a confirmed diagnosis of ASD, recruited from the ELENA cohort. A risk of premature delivery was associated, with an increased risk for severe autistic symptoms and placental pathologies and birth complications were associated with an increased risk of communication adaptive deficits, in multivariate analysis. Our results highlight the importance of systematic screening for these pre/perinatal factors, especially in mothers at risk of having a child with ASD. Highlights: Risk of premature delivery associated with a risk of severe autistic symptoms. Placental pathologies associated with a risk of communication adaptative deficits. Birth complications associated with a risk of communication adaptative deficits.