Microwave-Assisted Synthesis of Some 1, 3, 4-Oxadiazole Derivatives and Evaluation of Their Antibacterial and Antifungal Activity. (3rd December 2014)

• Record Type: Journal Article
• Authors: Swarnkar, Deepak; Ameta, Rakshit; Vyas, Ritu
• Other Names: Saavedra Joseph E. Academic Editor.
• Is Part Of: Organic chemistry international. Volume 2014(2014)
• Publication Date: 2014-12-03
• Subjects: Chemistry, Organic -- Periodicals; Chemistry, Organic; Periodicals; 547
• DOI: 10.1155/2014/694060
• Languages: English
• ISSNs: 2090-200X

Abstract

Abstract : A series of substituted 1, 3, 4-oxadiazole derivatives (3a–f) and (6a–f) have been synthesized from diphenylacetic acid hydrazide under microwave irradiation in various reaction conditions. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, and 1 H NMR. These targeted compounds have been tested for their antibacterial and antifungal activities compared to ampicillin and griseofulvin as standard drug. Compounds 3a, 3e, 3f, 6c, 6d, 6e, and 6d exhibited the maximum antibacterial activities while 3b, 3c, 3d, 3e, 6a, 6d, and 6e exhibited the maximum antifungal activities.