Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs. (5th April 2018)

• Record Type: Journal Article
• Authors: Cheng, Xiao-ting; Yang, Feng-bo; Jiang, Qing-qing; Zhang, Rong; Yang, Shi-ming; Yu, Ning
• Other Names: Chai Renjie Academic Editor.
• Is Part Of: Neural plasticity. Volume 2018(2018)
• Publication Date: 2018-04-05
• Subjects: Neuroplasticity -- Periodicals; 612.82
• DOI: 10.1155/2018/7513217
• Languages: English
• ISSNs: 2090-5904

Abstract

Abstract : Glucose is a fundamental source of energy for mammalian cells; however, whether glucose is taken up through the lateral walls of cochlear outer hair cells (OHCs) is unknown. The OHC lateral wall is complex, composed of a plasma membrane, cortical lattice, and subsurface cisternae. This study assessed the uptake of glucose by OHCs using live-cell microscopy and examined the distribution of glucose transporter isoforms by immunohistochemistry. We found that glucose transporter-4 was mostly expressed on the lateral wall of OHCs. Glucose crossed the lateral walls of OHCs via glucose transporters-4 mainly, and this process could be modulated. These results suggest that the lateral walls are involved in modulating energy transport into OHCs.