In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars. (30th May 2017)

• Record Type: Journal Article
• Authors: Silva, Isabela Rios da; Tiveron, Luciana Colombo Rodrigues da Cunha; da Silva, Marcos Vinicius; Peixoto, Alberto Borges; Carneiro, Carla Aparecida Xavier; Reis, M. A. dos; Furtado, Pedro Carvalho; Rodrigues, Bárbara Rocha; Rodrigues, Virmondes; Rodrigues, Denise Bertulucci Rocha
• Other Names: Strippoli Raffaele Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2017(2017)
• Publication Date: 2017-05-30
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2017/6573802
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation. The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group. Results showed that there was a predominance of women and nonwhite and direct black ancestry. Keloid showed a significant increase in total and type III collagen. Significantly, the expression of mRNA for TGF- β in keloid was increased, the expressions of IFN- γ, IFN- γ R1, and IL-10 were lower, and IFN- γ R1 and TNF- α had no statistical difference. Correlations between collagen type III and TGF- β mRNA expression were positive and significant, IFN- γ, IFN- γ R1, and IL-10 were negative and significant, and TNF- α showed no statistical difference. We conclude that there was a significant increase of total collagen in keloid and predominance of collagen type III compared to the controls, showing keloid as an immature lesion. There is a significant increase in TGF- β mRNA in keloid lesions, and a significant decrease in IFN- γ and IL-10, suggesting that these cytokines are related to keloid lesions.