Meta-Analysis of the Correlation Between PTPN22 Gene Polymorphisms and Susceptibility to Systemic Lupus Erythematosus. Issue 4 (July 2013)

• Record Type: Journal Article
• Authors: Shi, Lipu; Wei, Yanlin; Xun, Wen; Han, Dan
• Other Names: Zhang Jianhua guest-editor.; Zhang Xiaohui guest-editor.
• Is Part Of: Asia-Pacific journal of public health. Volume 25:Issue 4(2013)Supplement
• Page Start: 22S
• Page End: 29S
• Publication Date: 2013-07
• Subjects: PTPN22 gene -- systemic lupus erythematosus (SLE) -- 1858C/T polymorphism -- meta-analysis; Public health -- Pacific Area -- Periodicals; Public health -- Asia -- Periodicals; 362.1095
• DOI: 10.1177/1010539513496268
• Languages: English
• ISSNs: 1010-5395

Abstract

In this meta-analysis of the association between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus, 4 case–control studies, including one from China, were included. The studies included 1864 participants: 772 cases and 1092 controls. The meta-analysis showed that the 1858C/T polymorphism of the PTPN22 gene is correlated with systemic lupus erythematosus susceptibility, when assessed by distribution characteristics such as nationality, race, and region. A large sample size from the Chinese population is required for a further prospective study before causality can be established.