Investigation of the Risk Factors for Leukoaraiosis (LA). Issue 4 (July 2013)

• Record Type: Journal Article
• Authors: Zhang, Sijia; Kang, Xia
• Other Names: Zhang Jianhua guest-editor.; Zhang Xiaohui guest-editor.
• Is Part Of: Asia-Pacific journal of public health. Volume 25:Issue 4(2013)Supplement
• Page Start: 64S
• Page End: 71S
• Publication Date: 2013-07
• Subjects: leukoaraiosis (LA) -- magnetic resonance imaging (MRI) examination -- regression analysis -- risk factors -- investigation; Public health -- Pacific Area -- Periodicals; Public health -- Asia -- Periodicals; 362.1095
• DOI: 10.1177/1010539513493111
• Languages: English
• ISSNs: 1010-5395

Abstract

Leukoaraiosis (LA) describes abnormal changes in the cerebral white matter frequently seen on CT and MRI in older adults. Its appearance indicates mild brain injury, and it is often regarded as a mark of senile dementia. Through the analysis of related risk factors of 6000 patients with LA diagnosed by cranial MRI in our department, we found that age, cerebral infarction, lacunar infarction, history of brain hemorrhage, and increased triglycerides were risk factors for LA, and the relative risk odds ratio values were 2.135 (95% confidence interval [CI] = 1.874-2.501), 3.330 (95% CI = 1.922-3.997), 3.412 (95% CI = 2.986-3.512), 3.611 (95% CI = 2.054-9.147), and 1.457 (95% CI = 1.058-1.769), respectively. Through the identification of the risk factors for LA and effective interventions, the occurrence of dementia, stroke, and premature death may be effectively prevented.