Microwave-Assisted Three-Component "Catalyst and Solvent-Free" Green Protocol: A Highly Efficient and Clean One-Pot Synthesis of Tetrahydrobenzo[b]pyrans. (17th September 2014)

• Record Type: Journal Article
• Authors: Santra, Sougata; Rahman, Matiur; Roy, Anupam; Majee, Adinath; Hajra, Alakananda
• Other Names: Aly Shehata Ashraf Academic Editor.
• Is Part Of: Organic chemistry international. Volume 2014(2014)
• Publication Date: 2014-09-17
• Subjects: Chemistry, Organic -- Periodicals; Chemistry, Organic; Periodicals; 547
• DOI: 10.1155/2014/851924
• Languages: English
• ISSNs: 2090-200X

Abstract

Abstract : A green and highly efficient method has been developed for the one-pot synthesis of tetrahydrobenzo[ b ]pyrans via a three-component condensation of aldehydes, 1, 3-cyclic diketones, and malononitrile under MW irradiation without using any catalyst and solvent. This transformation presumably occurs by a sequential Knoevenagel condensation, Michael addition, and intramolecular cyclization. Operational simplicity, solvent and catalyst-free conditions, the compatibility with various functional groups, nonchromatographic purification technique, and high yields are the notable advantages of this procedure.