Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans. (28th March 2021)

• Record Type: Journal Article
• Authors: Simons, Pomme I. H. G.; Valkenburg, Olivier; Telgenkamp, Ine; van der Waaij, Koen M.; de Groot, David M.; Veeraiah, Pandichelvam; Bons, Judith A. P.; Taskinen, Marja‐Riitta; Borén, Jan; Schrauwen, Patrick; Rutten, Joost H. W.; Cassiman, David; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Schrauwen‐Hinderling, Vera B.; Hodson, Leanne; Brouwers, Martijn C. G. J.
• Is Part Of: Clinical endocrinology. Volume 95:Number 1(2021)
• Page Start: 101
• Page End: 106
• Publication Date: 2021-03-28
• Subjects: de novo lipogenesis -- liver fat -- non‐alcoholic fatty liver disease -- polycystic ovary syndrome -- sex hormone binding globulin -- stable isotopes; Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.14459
• Languages: English
• ISSNs: 0300-0664

Abstract

Abstract: Objective: Obesity and liver fat are associated with decreased levels of serum sex hormone binding globulin (SHBG). Laboratory studies suggest that hepatic de novo lipogenesis (DNL) is involved in the downregulation of SHBG synthesis. The aim of the present study was to address the role of DNL on serum SHBG in humans. Design: A cross‐sectional study examining the association between DNL, measured by stable isotopes, and serum SHBG, stratified by sex. Participants: Healthy men ( n = 34) and women ( n = 21) were combined from two cross‐sectional studies. Forty‐two per cent of participants had hepatic steatosis, and the majority were overweight (62%) or obese (27%). Results: DNL was inversely associated with SHBG in women (β: −0.015, 95% CI: −0.030; 0.000), but not in men (β: 0.007, 95% CI: −0.005; 0.019) ( p for interaction = .068). Adjustment for study population, age and body mass index did not materially change these results, although statistical significance was lost after adjustment for serum insulin. Conclusions: An inverse association between DNL and SHBG may explain the decreased SHBG levels that are observed in obesity, at least in women.