HAlign 3: Fast Multiple Alignment of Ultra-Large Numbers of Similar DNA/RNA Sequences. (2nd August 2022)

• Record Type: Journal Article
• Authors: Tang, Furong; Chao, Jiannan; Wei, Yanming; Yang, Fenglong; Zhai, Yixiao; Xu, Lei; Zou, Quan
• Editors: Crandall, Keith
• Is Part Of: Molecular biology and evolution. Volume 39:Number 8(2022)
• Publication Date: 2022-08-02
• Subjects: multiple sequence alignment -- suffix tree -- center star strategy -- common substring -- substring selection; Molecular biology -- Periodicals; Molecular evolution -- Periodicals; Evolution, Molecular -- Periodicals; Molecular Biology -- Periodicals; 572.8
• DOI: 10.1093/molbev/msac166
• Languages: English
• ISSNs: 0737-4038

Abstract

Abstract: HAlign is a cross-platform program that performs multiple sequence alignments based on the center star strategy. Here we present two major updates of HAlign 3, which helped improve the time efficiency and the alignment quality, and made HAlign 3 a specialized program to process ultra-large numbers of similar DNA/RNA sequences, such as closely related viral or prokaryotic genomes. HAlign 3 can be easily installed via the Anaconda and Java release package on macOS, Linux, Windows subsystem for Linux, and Windows systems, and the source code is available on GitHub (https://github.com/malabz/HAlign-3 ).