Short-Term Postoperative Cognitive Dysfunction and Inflammatory Response in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Pilot Study. (9th November 2017)

• Record Type: Journal Article
• Authors: Yu, Hui; Dong, Rui; Lu, Yayuan; Yang, Xi; Chen, Chang; Zhang, Zongze; Peng, Mian
• Other Names: Tsuji Fumio Academic Editor.
• Is Part Of: Mediators of inflammation. Volume 2017(2017)
• Publication Date: 2017-11-09
• Subjects: Inflammation -- Mediators -- Periodicals; Biological response modifiers -- Periodicals; Inflammation (Pathologie) -- Médiateurs; Immunomodulateurs; Biological response modifiers; Inflammation -- Mediators; Immunology; Autacoids; Immunologic Factors; Cell Adhesion Molecules; Cell Communication; Cytokines; Inflammation; Periodicals; Electronic journals; 616.0473
• DOI: 10.1155/2017/3605350
• Languages: English
• ISSNs: 0962-9351

Abstract

Abstract : Objectives . To assess the association between short-term postoperative cognitive dysfuction (POCD) and inflammtory response in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Design . A prospective cohort study. Setting . University medical centre. Participants . Fifty-one adult patients who had undergone CRS-HIPEC and twenty control participants. Measurements . The inflammatory marker levels in plasma and cognitive function were measured. Results . Twenty (39.2%, 20/51) patients developed POCD at 1 w after CRS-HIPEC. The patients with POCD had higher serum interleukin 1 β (IL-1 β ), serum amyloid A (SAA), S100 calcium-binding protein β (S-100 β ), and high mobility group box-1 protein (HMGB-1) levels at 1 and 24 h postoperatively than patients without POCD. There was an association between POCD and the maximum IL-1 β and S-100 β concentrations in serum, which remained following adjustment for age and FBS. Conclusion . In this pilot study, perioperative inflammatory marker levels increase significantly after CRS-HIPEC in adult patients, and such elevations are associated with the development of short-term cognitive dysfunction after this complex surgery. These results suggested the need for a larger RCT to replicate and confirm these findings.