CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration. Issue 5 (3rd March 2020)

Record Type:: Journal Article
Title:: CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration. Issue 5 (3rd March 2020)
Main Title:: CasRx-mediated RNA targeting prevents choroidal neovascularization in a mouse model of age-related macular degeneration
Authors:: Zhou, Changyang
Hu, Xinde
Tang, Cheng
Liu, Wenjia
Wang, Shaoran
Zhou, Yingsi
Zhao, Qimeng
Bo, Qiyu
Shi, Linyu
Sun, Xiaodong
Zhou, Haibo
Yang, Hui
Abstract:: Summary: RNA-targeting CRISPR system Cas13 offers an efficient approach for manipulating RNA transcripts in vitro. In this perspective, we provide a proof-of-concept demonstration that Cas13-mediated Vegfa knockdown in vivo could prevent the development of laser-induced CNV in mouse model of Age-related macular degeneration.
Is Part Of:: National science review. Volume 7:Issue 5(2020)
Journal:: National science review
Issue:: Volume 7:Issue 5(2020)
Issue Display:: Volume 7, Issue 5 (2020)
Year:: 2020
Volume:: 7
Issue:: 5
Issue Sort Value:: 2020-0007-0005-0000
Page Start:: 835
Page End:: 837
Publication Date:: 2020-03-03
Subjects:: Science -- Periodicals
505
Journal URLs:: http://nsr.oxfordjournals.org/ ↗
http://www.oxfordjournals.org/ ↗
DOI:: 10.1093/nsr/nwaa033 ↗
Languages:: English
ISSNs:: 2095-5138
Deposit Type:: Legaldeposit
View Content:: Available online (eLD content is only available in our Reading Rooms) ↗
Physical Locations:: British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store
Ingest File:: 23515.xml