Modeling human neuronal migration deficits in 3D. (February 2021)

• Record Type: Journal Article
• Authors: Reiner, Orly; Parichha, Arpan; Sapir, Tamar
• Is Part Of: Current opinion in neurobiology. Volume 66(2021)
• Page Start: 30
• Page End: 36
• Publication Date: 2021-02
• Subjects: Neurobiology -- Periodicals; 573.8
• DOI: 10.1016/j.conb.2020.09.005
• Languages: English
• ISSNs: 0959-4388

Abstract

Highlights: Cajal–Retzius (CR) cell migration in human and mouse is similar yet different. The expanded outer-subventricular zone is human-specific. Cortical organoids for modelling lissencephaly and periventricular brain heterotopia. Fusion organoids derived from patients demonstrated interneuron migration deficits. Abstract : During the past few decades, we have witnessed an impressive gain in the knowledge regarding the basic mechanisms underlying human neuronal migration disorders by the usage of mouse models. Nevertheless, despite the remarkable conservation both in the genetic encoded information and the developmental processes, there are still numerous important differences between human and mouse. This may explain the vast excitement following the realization that technological breakthroughs enabled generating tissue-like human-based organoids for modeling human neuronal migration diseases. This review will provide a short introduction on human and mouse neuronal migration processes, and highlight human brain organoid models of neuronal migration diseases.