Identification of a panel of mitotic spindle‐related genes as a signature predicting survival in lung adenocarcinoma. Issue 5 (21st October 2019)

• Record Type: Journal Article
• Authors: Zhang, Liwen; He, Miao; Zhu, Wenjing; Lv, Xuemei; Zhao, Yanyun; Yan, Yuanyuan; Li, Xueping; Jiang, Longyang; Zhao, Lin; Fan, Yue; Su, Panpan; Gao, Mengcong; Ma, Heyao; Li, Kai; Wei, Minjie
• Is Part Of: Journal of cellular physiology. Volume 235:Issue 5(2020:May)
• Page Start: 4361
• Page End: 4375
• Publication Date: 2019-10-21
• Subjects: biomarker -- Cox univariate and multivariate analysis -- gene set enrichment analysis (GSEA) -- lung adenocarcinoma (LUAD) -- mitotic spindle; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.29312
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Lung adenocarcinoma (LUAD) is one of the most malignant tumor types worldwide. Our objective was to identify a genetic signature that could predict the prognosis of patients with LUAD. We extracted gene data sets from The Cancer Genome Atlas and obtained differentially expressed genes that were highly expressed at every stage. These genes were analyzed using gene set enrichment analysis to obtain four biological processes associated with LUAD. Subsequently, Cox univariate and multivariate analyses were performed to generate four optimized models (G2M checkpoint, E2F targets, mitotic spindle, and glycolysis). We identified a mitotic spindle‐related signature ( KIF15, BUB1, CCNB2, CDK1, KIF4A, DLGAP5, ECT2, and ANLN ), which could be an independent prognostic indicator, to predict the prognosis of patients with LUAD. This new discovery should offer opportunities to explore the pathogenesis of LUAD and prove clinically useful in predicting LUAD patient prognosis. Abstract : Our objective was to identify a genetic signature that could predict the prognosis of patients with lung adenocarcinoma (LUAD). And we identified a mitotic spindle‐related signature (KIF15, BUB1, CCNB2, CDK1, KIF4A, DLGAP5, ECT2, and ANLN), which could be an independent prognostic indicator, to predict the prognosis of patients with LUAD.