ABO blood group as a risk factor for tuberculosis: A network meta-analysis. (March 2021)

• Record Type: Journal Article
• Authors: Chen, Hao; Horita, Nobuyuki; Matsumoto, Hiromi; Namkoong, Ho; Hara, Yu; Kobayashi, Nobuaki; Kaneko, Takeshi
• Is Part Of: International journal of infectious diseases. Volume 104(2021)
• Page Start: 701
• Page End: 707
• Publication Date: 2021-03
• Subjects: Tuberculosis -- ABO Blood-Group System -- Risk factor -- Network meta-analysis; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2021.01.057
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlight: Numerous studies of ABO blood group and tuberculosis risk have never been summarized. We included 15, 664 tuberculosis cases and 254, 610 controls from 28 studies. AB blood type was a risk factor for tuberculosis compared to A/B/O types. Abstract: Background: Despite numerous studies on ABO blood group and risk of tuberculosis, no consensus has been reached. Methods: We conducted a systematic review following the Meta-Analysis of Observational Studies in Epidemiology group statement. English language articles providing odds ratio data regarding tuberculosis risk among ABO groups were eligible. Least-squares approach random-model network and random-model pairwise meta-analyses were conducted. The protocol-specified primary outcome was tuberculosis risk among ABO groups in the form of odds ratios calculated via a network meta-analysis. Results: We identified 28 studies with 30 populations comprising 15, 664 patients with tuberculosis and 254, 610 controls. Subjects with AB blood type had a higher risk of becoming infected with tuberculosis than those with blood type O (odds ratio (OR) = 1.26, 95% confidence interval (CI): 1.14–1.38), A (OR = 1.25, 95% CI: 1.14–1.38), and B (OR = 1.22, 95% CI: 1.11–1.34). Pairwise comparison revealed that AB blood type was a risk factor for tuberculosis with OR = 1.23 (95% CI: 1.02–1.48) compared to other blood types. Region-based subgroup analyses suggested that the AB blood group was a substantial risk in Africa (OR = 1.78, 95% CI: 1.39–2.28) and India (OR = 1.48, 95% CI: 1.14–1.92). Conclusions: AB blood group is a risk factor for tuberculosis of a substantial magnitude in Africa and India.