Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry. (7th August 2022)

• Record Type: Journal Article
• Authors: Davis, Christopher; Li, Chun; Nie, Ruirui; Guzzardi, Norman; Dworakowska, Barbara; Sadasivam, Pragalath; Maher, John; Aboagye, Eric O.; Lu, Zhi; Yan, Ran
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 65:Number 10/11(2022)
• Page Start: 280
• Page End: 287
• Publication Date: 2022-08-07
• Subjects: iodotriazole -- phase transfer reagent -- radioiodination -- radioiodine; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3994
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract : Radioactive iodine isotopes play a pivotal role in radiopharmaceuticals. Large‐scale production of multi‐patient dose of radioiodinated nuclear medicines requires high concentration of radioiodine. We demonstrate that tetrabutylammonium chloride and methyltrioctylamonium chloride are effective phase transfer reagents to concentrate iodide‐124, iodide‐125 and iodide‐131 from the corresponding commercial water solutions. The resulting concentrated radioiodide, in the presence of either phase transfer reagent, does not hamper the chemical reactivity of aqueous radioiodide in the copper (II)‐mediated one‐pot three‐component click chemistry to produce radioiodinated iodotriazoles. Abstract : Large‐scale production of multipatient dose of radioiodinated nuclear medicines requires high concentration of radioiodine. We demonstrate that tetrabutylammonium chloride and methyltrioctylamonium chloride are effective phase transfer reagents to concentrate iodide‐124, iodide‐125, and iodide‐131 from the corresponding commercial water solutions. The resulting concentrated radioiodide, in the presence of either phase transfer reagent, does not hamper the chemical reactivity of aqueous radioiodide in the copper(II)‐mediated one‐pot three‐component click chemistry to produce radioiodinated iodotriazoles.