Potential immunotherapy for Alzheimer disease and age-related dementia. Issue 1 (31st March 2019)

• Record Type: Journal Article
• Authors: Schwartz, Michal; Arad, Michal; Ben-Yehuda, Hila
• Is Part Of: Dialogues in Clinical Neuroscience. Volume 21:Issue 1(2019)
• Page Start: 21
• Page End: 25
• Publication Date: 2019-03-31
• Subjects: Alzheimer disease -- immune checkpoint -- immunotherapy -- macrophage -- microglia
• DOI: 10.31887/DCNS.2019.21.1/mschwartz
• Languages: English
• ISSNs: 1958-5969

Abstract

Abstract : Emerging results support the concept that Alzheimer disease (AD) and age-related dementia are affected by the ability of the immune system to contain the brain's pathology. Accordingly, well-controlled boosting, rather than suppression of systemic immunity, has been suggested as a new approach to modify disease pathology without directly targeting any of the brain's disease hallmarks. Here, we provide a short review of the mechanisms orchestrating the cross-talk between the brain and the immune system. We then discuss how immune checkpoint blockade directed against the PD-1/PD-L1 pathways could be developed as an immunotherapeutic approach to combat this disease using a regimen that will address the needs to combat AD.