Distinct Clinicopathological Features and Prognosis of Emerging Young‐Female Breast Cancer in an East Asian Country: A Nationwide Cancer Registry‐Based Study. (7th May 2014)

• Record Type: Journal Article
• Authors: Lin, Ching‐Hung; Chuang, Po‐Ya; Chiang, Chun‐Ju; Lu, Yen‐Shen; Cheng, Ann‐Lii; Kuo, Wen‐Hung; Huang, Chiun‐Sheng; Lai, Mei‐Shu; You, San‐Lin; Tang, Chao‐Hsiun
• Is Part Of: Oncologist. Volume 19:Number 6(2014)
• Page Start: 583
• Page End: 591
• Publication Date: 2014-05-07
• Subjects: Breast cancer -- Estrogen -- Young -- Asia; Oncology -- Periodicals; Tumors -- Periodicals; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Oncology; Tumors; Neoplasms; Electronic journals; Periodicals; Periodicals; 616.994
• DOI: 10.1634/theoncologist.2014-0047
• Languages: English
• ISSNs: 1083-7159

Abstract

Abstract : Background: A rapid surge of young‐female breast cancer (YFBC) has been observed in Taiwan and other East Asian countries. We recently reported that these cases of YFBC, in contrast to their Western counterparts, are predominantly luminal A subtype. YFBC in Asia may have distinct clinicopathological features and outcomes. Methods: Data collected prospectively by participating hospitals were retrieved from the Taiwan Cancer Database. A total of 15, 881 women with newly diagnosed stage I–III breast cancer in 2002–2006 were included. The age at diagnosis was categorized into nine 5‐year groups (from <30 years to ≥65 years). Clinicopathological variables and patient disease‐free survival (DFS) were compared by age group. Results: The rates of stage I, estrogen receptor‐positive (ER+), and progesterone receptor‐positive breast cancer were higher in the younger patients (<50 years) than in the older patients (≥50 years). Univariate analysis showed that the 40–44 and 45–49 age groups were significantly associated with longer DFS than the other age groups. In the ER+ subgroup, multivariate analysis consistently showed that the 40–44 age group was significantly associated with longer DFS than the other age groups except for the 45–49 age group. In contrast, multivariate analysis of the ER‐negative subgroup revealed no significant difference of DFS between the 40–44 age group and other age groups. Conclusion: Emerging YFBC in Taiwan is uniquely associated with favorable pathological features and better outcomes and should not be regarded as the mirror image of its Western counterpart. Abstract : A rapid surge of young‐female breast cancer (YFBC) has been observed in Taiwan and other East Asian countries. This study showed that emerging YFBC in Taiwan is uniquely associated with favorable pathological features and better outcomes and should not be regarded as the mirror image of its Western counterpart. Abstract : 摘要 背景 . 在台湾地区以及东亚其他地区已发现年轻女性乳腺癌（YFBC）迅速飙升。我们最近报告了与西方国家相比，东亚YFBC病例主要为luminal A亚型。亚洲YFBC可能具有独特的临床病理学特征以及疾病转归。 方法 . 在台湾地区癌症数据库中进行检索，参与研究的医院前瞻性收集数据。共入组15 881例2002∼2006年新诊断的I∼III期乳腺癌女性。 确诊时年龄分成9组，每5岁为1个年龄组（<30岁∼ ≥65岁）。比较各年龄组的临床病理学变量与患者无疾病生存期（DFS）。 结果 . 年轻患者（< 50岁）中I期、雌激素受体阳性（ER+）、孕激素受体阳性乳腺癌发生率高于年老患者（≥ 50岁）。单变量分析显示，40 ∼ 44岁与45 ∼ 49岁年龄组DFS显著长于其他年龄组。对于ER+亚型，多变量分析一致显示，除外45 ∼ 49岁年龄组，40 ∼ 44岁年龄组DFS显著长于其他年龄组。相反，对ER阴性亚型的多变量分析表明，40 ∼ 44岁年龄组DFS与其他年龄组之间差异无统计学意义。 结论 . 台湾地区出现的YFBC病例具有良好的病理学特征以及更好的转归，不应与西方病例等同视之。 The Oncologist 2014;19:583–591