Unfractionated heparin reduces hepcidin levels in critically ill patients. Issue 5 (27th May 2021)

• Record Type: Journal Article
• Authors: Vagionas, Dimitrios; Politou, Marianna; Kompoti, Maria; Papadakis, Dimitrios‐Dorotheos; Kostakou, Eirini; Theodoulou, Danai; Kaniaris, Evangelos; Rovina, Nikoletta; Koutsoukou, Antonia; Vasileiadis, Ioannis
• Is Part Of: Internal medicine journal. Volume 51:Issue 5(2021)
• Page Start: 797
• Page End: 801
• Publication Date: 2021-05-27
• Subjects: anaemia in the critically ill -- anti‐hepcidin effect of heparins -- hepcidin levels -- iron metabolism -- pleiotropic action of heparins; Medicine -- Periodicals; 616
• DOI: 10.1111/imj.15317
• Languages: English
• ISSNs: 1444-0903

Abstract

Abstract : A strong anti‐hepcidin activity has been observed in heparins. Mean hepcidin levels were significantly reduced compared to baseline, following the first day of unfractionated heparin administration in critically patients. Heparin displayed a strong independent negative association with hepcidin. These results may lead to future treatment methods of forms of anaemia characterised by hepcidin excess, common among the critically ill.