Does serum vitamin D level affect the association between cardiovascular health and cognition? Results of the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) study. (27th September 2020)

• Record Type: Journal Article
• Authors: Jeon, Y. J.; Jung, S. J.; Kim, H. C.
• Is Part Of: European journal of neurology. Volume 28:Number 1(2021)
• Page Start: 48
• Page End: 55
• Publication Date: 2020-09-27
• Subjects: cardiovascular health -- cognitive disorders and dementia -- epidemiology; Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.14496
• Languages: English
• ISSNs: 1351-5101

Abstract

Abstract : Background and purpose: Few studies have assessed the role of vitamin D in the association between cardiovascular risk factors and cognitive function. Here, the aim was to investigate the association between cardiovascular health (CVH) and cognitive function according to vitamin D level in a middle‐aged Korean population. Methods: This cross‐sectional study included 840 men and 1811 women (mean age 57.2 years) from the Cardiovascular and Metabolic Diseases Etiology Research Center study baseline enrolment (2013–2018). Life's Simple 7 tools from the American Heart Association were used to assess CVH. Cognitive function was evaluated using the Mini‐Mental State Estimation for Dementia Screening (MMSE‐DS), and the serum 25‐hydroxyvitamin D level was measured. Results: In the adjusted generalized linear regression models, no significant association between a high Life's Simple 7 score (4–7 metric at optimal level) and MMSE‐DS score ( β = 0.01, P = 0.93) was found. Amongst men with a high vitamin D level, the high Life's Simple 7 score group showed a significantly higher MMSE‐DS score ( β = 0.48, P = 0.03). However, amongst men in the low vitamin D group, the association was opposite with no statistical significance ( β = −0.23, P = 0.08). In women, the results were similar, but both strata according to vitamin D level showed no statistical significance. Conclusions: Our findings suggest that vitamin D is an effect modifier in the association between CVH and cognition, especially in men. Abstract : Interaction between Life's Simple 7 (LS7) score and serum vitamin D level estimating MMSE‐DS, stratified by gender ( N = 2651).