Peripheral follicular helper T cells in acute viral diseases: a perspective on dengue. (6th March 2019)

• Record Type: Journal Article
• Authors: Sánchez-Vargas, Luis A; Mathew, Anuja
• Is Part Of: Future virology. Volume 14:Number 3(2019)
• Page Start: 161
• Page End: 169
• Publication Date: 2019-03-06
• Subjects: antibodies -- B cells -- dengue -- Ebola -- germinal center -- influenza -- pTFH -- TFH -- TFR -- vaccine; Virology -- Periodicals; Virus diseases -- Treatment -- Periodicals; 616.9101
• DOI: 10.2217/fvl-2018-0197
• Languages: English
• ISSNs: 1746-0794

Abstract

Follicular helper T cells (TFH ) are a predominant subset of CD4 + T cells specialized in providing help to B cells in germinal centers and necessary to generate T cell-dependent antibody responses. Peripheral TFH (pTFH ) are the counterpart of TFH found in the circulation, which resemble TFH in many aspects of their phenotype and function. The CD4 + pTFH subset has received a lot of interest recently because they are easy to access and have the potential to serve as a biomarker for long-lasting humoral immunity. This review will discuss recent findings of pTFH in human acute viral diseases with a focus on dengue infection.