Prognostic value of dynamic albumin-to-alkaline phosphatase ratio in limited stage small-cell lung cancer. (15th January 2019)

• Record Type: Journal Article
• Authors: Li, Xiaogang; Li, Butuo; Zeng, Haiyan; Wang, Shijiang; Sun, Xindong; Yu, Yishan; Wang, Linlin; Yu, Jinming
• Is Part Of: Future oncology. Volume 15:Number 9(2019)
• Page Start: 995
• Page End: 1006
• Publication Date: 2019-01-15
• Subjects: albumin-to-alkaline phosphatase ratio -- dynamically -- limited stage small-cell lung cancer -- prognostic -- survival analysis; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2018-0818
• Languages: English
• ISSNs: 1479-6694

Abstract

Aim: To dynamically investigate the prognostic value of albumin-to-alkaline phosphatase ratio (AAPR) in limited stage small-cell lung cancer.Materials & methods: The AAPR within 1 week before and after chemoradiation therapy (pre- and post-AAPR) was collected and analyzed.Results: Patients with low pre- or post-AAPR had shorter overall survival and progression-free survival than the high groups (p-values all <0.05). Post-AAPR was an independent prognostic factor for progression-free survival (p = 0.007) and overall survival (p = 0.003). The integration of pre- or post-AAPR improved the prognostic ability of Tumor, Node, Metastasis stage alone (0.55–0.64 and 0.68, respectively).Conclusion: Post-AAPR is a reliable prognostic factor for limited stage small-cell lung cancer patients. The complementary value of AAPR to Tumor, Node, Metastasis stage is worth further validation in the future.