Antithrombotic treatment patterns in patients with atrial fibrillation in Italy pre- and post-DOACs: the REPAIR study. (21st January 2019)

• Record Type: Journal Article
• Authors: Esposti, Luca D; Briere, Jean-Baptiste; Bowrin, Kevin; Diego, Sangiorgi; Perrone, Valentina; Pasquale, Giuseppe Di
• Is Part Of: Future cardiology. Volume 15:Number 2(2019)
• Page Start: 109
• Page End: 118
• Publication Date: 2019-01-21
• Subjects: antithrombotic treatment patterns -- direct oral anticoagulants -- nonvalvular atrial fibrillation -- OAC prescription -- real-world data; Cardiology -- Research -- Periodicals; 616.12005
• DOI: 10.2217/fca-2018-0009
• Languages: English
• ISSNs: 1479-6678

Abstract

Aim: To evaluate antithrombotic treatment patterns in patients in Italy with nonvalvular atrial fibrillation (NVAF) before and after direct oral anticoagulants (DOACs) were approved.Methods: This analysis included patients with a discharge diagnosis of NVAF in 2010 and 2014, which constituted the pre- and post-DOACs populations, respectively.Results: Approximately 90% of patients were eligible for oral anticoagulant (OAC) therapy. Overall use of OACs increased from 38% in 2010 to 45% in 2014; use of antiplatelet therapy decreased from 36 to 25%. Approximately 14% of eligible patients remained untreated.Conclusion: Although an improvement in OAC prescription was observed post-DOACs launch, treatment patterns in Italy suggest that a proportion of patients with NVAF are still undertreated or do not receive appropriate therapy.