A case report of high-grade astroblastoma in a young adult. (28th February 2019)

• Record Type: Journal Article
• Authors: Bhalerao, Sagar; Nagarkar, Rajnish; Adhav, Aditya
• Is Part Of: CNS oncology. Volume 8:Number 1(2019)
• Publication Date: 2019-02-28
• Subjects: astroblastoma -- brain neoplasm -- brain tumor -- magentic resonance imaging; Central nervous system -- Tumors -- Periodicals; 616.99481
• DOI: 10.2217/cns-2018-0012
• Languages: English
• ISSNs: 2045-0907

Abstract

Astroblastoma is an uncommon neuroepithelial primary tumor of the brain which is of uncertain origin. We present a case of high-grade astroblastoma in an 18-year-old female with a severe headache, loss of appetite, vomiting and generalized weakness. The patient had undergone a right frontoparietal craniotomy. Large subfalcine meningioma was excised. The lesion was suspected to be a meningioma. Primary radiological investigation revealed a 6.8 cm × 5.8 cm × 5.4 cm lesion. Although the radiological and intraoperative findings were of an extra-axial tumor, the histology and immunophenotype was of an astroblastoma. The patient was treated with cyclophosphamide, cisplatin and etoposide chemotherapy regimen. The patient was later treated with bi-weekly bevacizumab. The patient had improved symptomatically post-chemotherapy. However, there was no significant difference in lesion size. The patient died after 2 weeks. The prognosis of patients with astroblastoma is extremely poor as observed in our case.