Evaluation of human serum S100B protein as a prognostic factor in nonmetastatic breast cancer patients. (5th March 2019)

• Record Type: Journal Article
• Authors: Homaei Shandiz, Fatemeh; Ghaffarzadegan, Kamran; Jahani Fariman, Saeed; Jannati, Mahdi; Elyasi, Sepideh; Mohammadpour, Amir Hooshang
• Is Part Of: Breast cancer management. Volume 7:Number 4(2018)
• Publication Date: 2019-03-05
• Subjects: nonmetastatic breast cancer -- prognostic factor -- S100B protein; Breast -- Cancer -- Periodicals; Breast -- Cancer -- Treatment -- Periodicals; 616.9944905
• DOI: 10.2217/bmt-2018-0008
• Languages: English
• ISSNs: 1758-1923

Abstract

Aim: The aim of this study was the evaluation of S100B prognostic role in nonmetastatic breast cancer patients, excluding confounding factors.Patients & method: 79 breast cancer patients, who fulfilled inclusion and exclusion criteria, were enrolled in the study. Before any adjuvant chemotherapy or surgery, the serum level of S100B was determined. All patients were followed up for 5 years, particularly regarding cancer recurrence and patients' survival.Results: 42% of the patients experienced no recurrence after 5 years and cumulative risk of recurrence was 0.86. There was no significant correlation between serum level of protein S100B and recurrence rate in 5 years (p = 0.59).Conclusion: According to the results, the serum levels of S100B protein may have no prognostic role in nonmetastatic breast cancer.